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KMID : 0391419910010010045
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Korean Journal of Lipidology
1991 Volume.1 No. 1 p.45 ~ p.56
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Modulation of Lipid Metabolism in Serum and Liver by Dietary Fat in Normotensive and Spontaneously Hypertensive Rats
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조성희
신응남/서미영/이원정
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Abstract
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To study differences in lipid metabolism of normotensive Wistar and spontaneously hypertenisve rats (SHR), the responses to various dietary fats were compared in serum and liver. Weanling SHRs and Wistars were fed diets containing 5% (w/w)
mackerel
oil(MO), soybean oil(SO) or beef tallow (BT) for 8 weeks. Body weight gains almost stopped in SHRs after 6 weeks of feeding when hypertension became obvious, but continued in Wistar. Changes in dietary fat caused no difference in growth of either
SHRs
or Wistars. MO and SO reduced blood pressure increase in SHRs from 7th week, compared to BT. Serum total cholesterol levels did not differ between two strains but those of HDL-cholesterol and triglyceride (TG) were significantly low in SHRs.
Effect
of
the type of dietary fat on serum lipid was not marked except TG levels were decreased in SHRs fed MO and SO. Liver lipid contents appeared to be higher in SHR and little affected by dietary fat. Major dietary fatty acids were incorporated into
serum and
liver phospholipid, but the degree of incorporation and the ratio of arachidonic/linoleic acid lower in SHRs than in Wistars. Hepatic glucose-6-phosphate dehydrogenase and malic enzyme activities remarkably reduced in MO and SO groups, compared
to
BT
group, the only one in which lowering effect of enzyme activities was shown by hypertension.
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KEYWORD
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